![]() ![]() It also identified an unexpected trend toward increased time in bed and amyloid deposition. This study was critical in identifying a greater temporal window for key clinical interventions to be made to address sleep abnormalities because it was the first to show that changes in sleep are associated with Alzheimer's disease brain changes prior to symptom onset (in preclinical disease). In May 2013, a team including Ju and her mentor David Holtzman showed that sleep quality, but not necessarily sleep quantity, is associated with amyloid deposition in preclinical Alzheimer's disease, publishing their findings in JAMA Neurology. The lab's projects include studying the effect of slow-wave sleep on amyloid-beta dynamics REM sleep behavior disorder sleep and circadian rhythms in Alzheimer's disease as well as biomarkers of Alzheimer's disease in sleep and electroencephalography (EEG). The Yo-El Ju Lab studies sleep and neurodegenerative diseases, focusing on two areas: sleep and Alzheimer's disease, and REM sleep behavior disorder and its relationship to synucleinopathies such as Parkinson's disease. Ju started working as an Assistant Professor in the Department of Neurology at Washington University School of Medicine in 2011 and is currently the Barbara Burton and Reuben Morriss III Professor of Neurology. ![]() in Clinical Investigation from Washington University in St. During this period, Ju also studied rapid eye movement (REM) sleep behavior disorder with an eye to future treatments. After this, Ju went on to specialize in sleep medicine, completing clinical and research fellowships in the discipline of the Washington University Multidisciplinary Sleep Medicine Center from 2009 to 2011, where she examined the relationship between Alzheimer's disease and circadian rhythms. ![]() Louis, completing a residency in neurology in 2009. After graduating from medical school, Ju moved to Washington University in St. in 2005 from Columbia University Vagelos College of Physicians and Surgeons, where she was a member of Alpha Omega Alpha, a national medical honor society, and won the Glasgow-Rubin Achievement Award for women graduating in the top 10% of their class. While studying at Harvard, she received the John Harvard College Scholarship (awarded to top 5% of class) and conducted research in neuronal cell biology and tissue engineering in the lab of Paul Janmey and Thomas Stossel under the mentorship of Lisa A. ![]() She attended Harvard College for her undergraduate studies, graduating Magna Cum Laude in 2001 with a B.A. She attended Rift Valley Academy in Kijabe, Kenya for high school and later transferred to Fairfax High School in Los Angeles, U.S. As of April 2023, the most cited work from her lab is their 2017 paper in Brain: A Journal of Neurology that showed cerebrospinal fluid (CSF) amyloid-beta protein level increases due to slow-wave sleep disruption. Ju's team has made multiple significant contributions to the field of sleep medicine and neurology in unveiling the complex relationship between sleep, amyloid deposition and neurodegenerative diseases such as Alzheimer's, opening new possibilities for clinical treatment. Clinically, she sees patients at Barnes-Jewish Hospital for parasomnia, narcolepsy, restless legs syndrome, and obstructive sleep apnea. She co-directs the Center on Biological Rhythms and Sleep (COBRAS) and is a member of the Hope Center for Neurological Diseases at Washington University. Yo-El Ju is the Barbara Burton and Reuben Morriss III Professor of Neurology at the Washington University School of Medicine. Harvard college ( B.A.), Columbia University Vagelos College of Physicians and Surgeons ( M.D.) ![]()
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